The Korean Journal of Nuclear Medicine (대한핵의학회지)

The Korean Society of Nuclear Medicine (대한핵의학회)
권호 표지

Accumulation of $^{l69}Yb$ Citrate in Tumor Bearing Mice

흰쥐 육종 180에서 $^{169}Yb-Citrate$의 종양 친화성

  • Kim, Jang-Hee (Nuclear Medicine Laboratory, Korea Cancer Center Hospital, KAERI) ;
  • Hong, Sung-Woon (Nuclear Medicine Laboratory, Korea Cancer Center Hospital, KAERI) ;
  • Lim, Sang-Moo (Nuclear Medicine Laboratory, Korea Cancer Center Hospital, KAERI) ;
  • Lee, Jhin-Oh (Nuclear Medicine Laboratory, Korea Cancer Center Hospital, KAERI)
  • 김장휘 (원자력병원 핵의학연구실) ;
  • 홍성운 (원자력병원 핵의학연구실) ;
  • 임상무 (원자력병원 핵의학연구실) ;
  • 이진오 (원자력병원 핵의학연구실)
  • Published : 1988.05.25
Download PDF
⟨ Previous Next ⟩

Abstract

Tumor localizing properties of $^{67}Ga$ citrate and $^{169}Yb$ citrate were studies with sarcoma 180 bearing mice. To compare precisely the accumulation of $^{67}Ga$ citrate and $^{169}Yb$ citrate in tumor tissue itself, $^{67}Ga$ and l63yb were administered simultaneously as a mixture of same chemical form of citrate. The yield of $^{169}Yb$ labeled citrated and the of radiopharmaceuticals purity was identified more than 90% by chromatography on silica gel plates. $^{67}Ga$ and $^{169}Yb$ were injected into mice and the mice were killed at 3, 24, and 48 hours following intraperitoneal injection of the radiopharmaceuticals. The retention value of $^{67}Ga$ and $^{169}Yb$ in tumor was similar but they differ from each other markedly in normal tissue distribution. $^{169}Yb$ citrate is cleared up from blood more rapidly than $^{67}Ga$ citrate, and a high tumor to blood ratio is achieved shortly after injection.

Keywords