The Korean Journal of Nuclear Medicine (대한핵의학회지)

The Korean Society of Nuclear Medicine (대한핵의학회)
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The Eye/Brain Radioactivity Ratio for Assessment of Graves' Ophthalmopathy

Graves병 안구증에서 $^{99m}Tc-DTPA$ 뇌신티그라피를 이용한 안구/뇌 방사능비에 관한 연구

  • Lee, B.W. (Department of Internal Medicine, National Medical Center) ;
  • Sung, S.K. (Department of Internal Medicine, National Medical Center) ;
  • Park, W. (Department of Internal Medicine, National Medical Center) ;
  • Suh, K.S. (Department of Internal Medicine, National Medical Center) ;
  • Choi, D.J. (Department of Internal Medicine, National Medical Center) ;
  • Kim, J.S. (Department of Internal Medicine, National Medical Center)
  • Published : 1988.05.25
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Abstract

In Graves' disease, changes in orbital tissue and structure are casued by inflammatory infiltation, which induces increase of capillary permeability and breakdown of blood-tissue barriers. Using the uptake of $^{99m}Tc-DTPA$ in inflammatory lesion, Eye/Brain radioactivity ratios in brain scintigraphy were evaluated in 15 normal controls and 40 Graves' patients. The results were as follows; 1) Eye/Brain radioactivity ratio was significantly higher in Graves' ophthalmopthy group than in control group (p < 0.005). 2) In Graves' ophthalmopathy, Eye/Brain radioactivity ratio was significantly higher in active (progressive) group than in inactive (non-progressive) group (p < 0.05). 3) There was no correlation between class of ATA classification of Graves' ophthalmopathy and Eye/Brain radioactivity ratio. 4) There was no correlation between Eye/Brain radioactivity ratio and serum activity of TBII. In conclusion, Eye/Brain radioactivity ratio using $^{99m}Tc-DTPA$ brain scintigraphy may be useful to determine the activity of Graves' ophthalmopathy and whether treatment of Graves' ophthalmopathy is necessary or not.

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