Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Synthesis of Acyclic Nucleosides of 2-Thio-Pyrimidines and -Purines Using a New Coupling Agent of Lithium Bromide

  • Kim, Joong-Young (Department of Chemistry, Korea Advanced Institute of Science and Technology) ;
  • Kim, Yong-Hae (Department of Chemistry, Korea Advanced Institute of Science and Technology)
  • Published : 1988.10.20
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Abstract

Acyclic nucleosides, 1-[[1,3-bis(benzyloxy)-2-propoxy]methyl]-2-thiopyrimidine, 9-[[1,3-bis(benzyloxy)-2-propoxy]methyl]-6-amino -2-thiopurine, 1-(2-acetoxyethoxymethyl)-2-thiopyrimidine, and 9-[[1,3-bis(benzyloxy)-2-propoxy]methyl]-6-amino -2-thiopurine have been synthesized by coupling pyrimidine and purine bases with acyclic acetates using a new coupling reagent of lithium bromide in the presence of trifluoro acetic acid in acetonitrile.

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References

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Cited by

  1. ChemInform Abstract: Synthesis of Acyclic Nucleosides of 2‐Thio‐pyrimidines and ‐purines Using a New Coupling Agent of Lithium Bromide. vol.20, pp.16, 1988, https://doi.org/10.1002/chin.198916337
  2. Acyclonucleosides: Part 2. diseco -Nucleosides vol.68, pp.None, 1997, https://doi.org/10.1016/s0065-2725(08)60360-8