Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Synthesis of new Hydantoin-3-Acetic acid Derivatives

  • Oh, Chang-Hyun (Department of Chemistry, Korea Advanced Institute of Science and Technology) ;
  • Kang, Yong-Koo (Department of Chemistry, Korea Advanced Institute of Science and Technology) ;
  • Park, Sang-Woo (Department of Chemistry, Korea Advanced Institute of Science and Technology) ;
  • Cho, Jung-Hyuck (Department of Chemistry, Korea Advanced Institute of Science and Technology) ;
  • Kwon, Soon-Kyung (Department of Pharmacy, Duksung Womens' University)
  • Published : 1988.08.20
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Abstract

Through the Bucherer-Berg method, new 5-alkylthiomethyl or 5-alkylsulfonylmethylhydantoins were prepared. The reaction of ethyl chloroacetate with these compounds gave 3-acetate and the subsequent hydrolysis with dilute sodium hydroxide resulted in 3-hydantoinacetic acid derivatives. These products are expected to exhibit anti-inflammatory and analgestic activities.

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References

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Cited by

  1. ChemInform Abstract: Synthesis of New Hydantoin‐3‐acetic Acid Derivatives. vol.20, pp.8, 1988, https://doi.org/10.1002/chin.198908173
  2. Synthesis of 5-Aslkylthio (or sulfonyl) methyl-5-m-methoxy-phenylhydantion-3-acetic Acid Derivatives vol.16, pp.4, 1993, https://doi.org/10.1007/bf02977524
  3. Synthesis of New Hydantoin-3-Ethanethioi Derivatives vol.17, pp.4, 1994, https://doi.org/10.1007/bf02980462
  4. Synthesis, Crystal Structure, Spectroscopic and Thermal Properties of a Novel Complex of Hydantoin-5-acetic acid with Co(II) vol.23, pp.3, 1988, https://doi.org/10.1007/s10904-013-9822-0
  5. The Bucherer-Bergs Multicomponent Synthesis of Hydantoins-Excellence in Simplicity vol.26, pp.13, 1988, https://doi.org/10.3390/molecules26134024