한국환경보건학회지 (Journal of Environmental Health Sciences)
- 제14권1호
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- Pages.115-122
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- 1988
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- 1738-4087(pISSN)
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- 2233-8616(eISSN)
Captafol 免疫毒性에 미치는 Ethanol의 영향
Studies on the Effect of Captafol and Ethanol the Murine Immune System
초록
Captafol (1H-Isoindole-1.3(2H)-dione, 3a, 4, 7, 7a-tetrahydro-2-[1, 1, 2, 2-tetrahydroethyltkio]) is widely used as fungicide in agriculture. Immune modulatory effects of captafol and ethanol were studied in mice. Mice administered captafol intra peritoneally every other day for 5 times, and ethanol per os as captafol. Mice were sensitized and challenged with sheep red blood cells, serum antibody titer, foot pad swelling, and rosette forming cell number were mediated immune response. 1. The result show that humoral immune response and cell mediatea response were suppressed by captafol. 2. Especially effect of ethanol on the captafol immune response were significantly suppressed the humoral immune response and cell mediated immune response.
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