Toxicological Research
- Volume 4 Issue 2
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- Pages.107-115
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- 1988
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- 1976-8257(pISSN)
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- 2234-2753(eISSN)
THE EFFECTS OF ALTERING THE HEPATIC DRUG METABOLIZING ENZYME ACTIVITY ON THE ACUTE TOXICITY OF DIETHYL-4-NITROPHENYL PHOSPHOROTHIOATE (PARATHION) IN FEMALE RATS1.
- Kim, Young-Chul (College of Pharmacy,Seoul National University) ;
- Park, Jae-Hwa (College of Pharmacy,Seoul National University) ;
- Lim, Hye-Kyung (College of Pharmacy,Seoul National University)
- Published : 1988.12.01
Abstract
The effects of altering the hepatic mixed-function oxidase(MFO) activities on the acute toxicity of parathion were examined in female rats. Phenobarbital sodium pretreatment (50mg/kg/day, i.p.) for 4 consecutive days has resulted in significant decreases in the toxicity of parathion (2 or 4 mg/kg, i.p.) as determined by lethality and cholinesterase activities wheras the toxicity arising from a single dose of CCl4(2 mmol/kg, i.p.) 24 hr prior to parathion challenge was potentiated.
Keywords
- parathion;
- phenobarbital;
- carbon tetrachloride;
- SKF 525-A;
- CoCl2;
- acetylcholinesterase activity;
- mixed-function oxidase system;
- MFO