Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)
- Volume 9 Issue 1
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- Pages.73-78
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- 1988
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- 1229-0807(pISSN)
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- 2288-9396(eISSN)
Formation of Polyelectrolyte Complex Hydrogel and its Application to Drug Delivery System
고분자간전해질복합체로 된 hydrogel의 형성과 약의 방출성질
- Cho, Chong-Su (Dept. of Polymer Eng., Chunnam National Univ) ;
- Kim, Seun-Ung (Dept. of Polymer Eng., Chunnam National Univ) ;
- Kim, Hack-Joo (Sam Yang General Laboratory)
- Published : 1988.06.01
Abstract
The polymer electrolyte complex hydrogels consisting of poly (methacrylic acid) and poly (4-vinylpyrridine) were formed and 5-flurouracil and pilocarpine drugs were loaded on their hydrogels. Cumulative 5-FU released from PEC hydrogel was affected by the degree of loading and release rate of 5-FU was followed by the monolithic type. Cumulative pilocarpine released from PEC hydrogel increased by ionic interaction between cationic pilocarpine and anionic PMA. Release rate showed the zero order after burst effect.
Keywords