Journal of Pharmaceutical Investigation
- 제18권3호
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- Pages.113-123
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- 1988
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
수용성 폴리파라시클로판류와 약물과의 상호작용(제 2보) -수용액중 수용성 폴리파라시클로판류와 형광 소수 나프탈렌 유도체류와의 상호 작용-
Interactions between Water-Soluble Polyparacyclophanes and Drugs (II) -Interaction between Water-Soluble Polyparacyclophanes and Fluorescent Hydrophobic Naphthalene Derivatives in Aqueous Solution-
- Chun, In-Koo (Department of Pharmacy, Dongduck Women's University) ;
- Lee, Min-Hwa (College of Pharmacy, Seoul National University) ;
- Kim, Shin-Keun (College of Pharmacy, Seoul National University)
- 발행 : 1988.09.20
초록
A series of water-soluble polyparacyclophanes bearing two diphenylmethane or two diphenyl ether skeletons were investigated to develop useful host compounds by using 1-anilinonaphthalene-6-sulfonate (ANS) and 2-p-toluidinylnaphthalene-6-sulfonate (TNS) as fluorescent hydrophobic substrates in aqueous solution. It was noteworthy that remarkable fluorescent enhancements and blue shifts of ANS and TNS were observed only in the presence of 1,6,20,25-tetraaza[6.1.6.1] paracyclophane (CPM 44) and 1,6,21,27-tetraaza [7.1.7.1] paracyclophane (CPM 55) for diphenylmethane skeleton, and 1,7,21,27-tetraaza-14,34-dioxa [7.1.7.1] paracyclophane (CPE 55) and 1,8,22,29-tetraaza-15,36-dioxa [8.1.8.1] paracyclophane (CPE 66) for diphenyl ether skeleton, comparing with
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