Journal of Pharmaceutical Investigation

  • 제18권3호
  • /
  • Pages.99-105
  • /
  • 1988
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  • 2093-5552(pISSN)
  • /
  • 2093-6214(eISSN)
한국약제학회 (The Korean Society of Pharmaceutical Sciences and Technology)
권호 표지

푸로세미드의 안정성 및 생체내 이용율에 미치는 ${\beta}-$시클로덱스트린의 영향

Influence of ${\beta}-Cyclodextrin$ on Stability and Bioavailability Of Furosemide

  • 한건 (충북대학교 약학대학) ;
  • 유병권 (충북대학교 약학대학)
  • Han, Kun (College of Pharmacy, Chungbuk National University) ;
  • Yu, Byeong-Kwun (College of Pharmacy, Chungbuk National University)
  • 발행 : 1988.09.20
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초록

Inclusion complex formation of furosemide with ${\beta}-cyclodextrin({\beta}-CyD)$ in solid state was confirmed by X-ray diffractometry, IR spectroscopy and differential scanning calorimetry (DSC). The solid complexes of ${\beta}-CyD$ with furosemide in molar ratio of 2 : 1 were prepared by solvent evaporation method. The photodegradation of furosemide in alkaline solution under the light and the hydrolysis of furosemide in acidic solution were not inhibited by complex formation with ${\beta}-CyD$. However, the bioavailability of furosemide was improved by complex formation with ${\beta}-CyD$ after oral administration to rats.

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