Journal of Pharmaceutical Investigation
- Volume 18 Issue 2
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- Pages.89-97
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- 1988
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Interactions between Water-Soluble Polyparacyclophanes and Drugs (I) -Design and Synthesis of Water-Soluble Polyparacyclophanes Containing Diphenyl Ether Skeletons-
수용성 폴리파라시클로판류와 약물과의 상호작용 (제1보) -디페닐에텔을 골격으로 하는 수용성 폴리파라시클로판류의 설계 및 합성-
- Chun, In-Koo (Department of Pharmacy, Dongduck Women's University) ;
-
Lee, Min-Hwa
(College of Pharmacy, Seoul National University)
;
- Kim, Shin-Keun (College of Pharmacy, Seoul National University)
- Published : 1988.06.20
Abstract
A series of novel water-soluble paracyclophanes containing two diphenyl ether skeletons and two bridging aliphatic chains of various length were designed and prepared to develop artificial host compounds which might provide efficient hydrophobic field. They were 1,5,19,23-tetraaza-12,30-dioxa[5,1.5.1] paracyclophane (6), 1,6,20,25-tetraaza-13,32-dioxa[6.1.6.1]paracyclophane (7), 1,7,21,27-tetraaza-14,34-dioxa[7.1.7.1]paracyclophane (8) and 1,8,22,29-tetraaza-15,36-dioxa[8.1.8.1]paracyclophane (9). As the corresponding acyclic analogue, 4,4'-dimethylaminodiphenyl ether (11) was synthesized for the comparative study of further host-guest interaction.
Keywords