Journal of Pharmaceutical Investigation
- 제18권2호
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- Pages.43-47
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- 1988
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
수용성 담체와의 공침물 형성에 의한 메토클로프라미드의 용출 증가
Dissolution Enhancement of Metoclopramide by Coprecipitation with Water-Soluble Carriers
- Yong, Jae-Ick (College of Pharmacy, Sookmyung Women's University) ;
- Jeong, Cha-Ok (College of Pharmacy, Sookmyung Women's University)
- 발행 : 1988.06.20
초록
In order to increase the dissolution characteristics of relatively water-insoluble metoclopramide (MCP), coprecipitates of MCP with polyvinylpyrrolidone (PVP), polyethylene glycol (PEG) 1000, 4000 or 6000 were prepared in various drug to polymer ratios. The dissolution rate of MCP-PVP coprecipitate was greater than those of MCP alone, MCP-PVP physical mixture and MCP-PEG coprecipitates. The dissolution rate of MCP-PEG 6000 coprecipitate was greater than those of MCP-PEG 1000 and MCP-PEG 4000 coprecipitates. The dissolution half-lives
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