Journal of Pharmaceutical Investigation
- Volume 18 Issue 1
- /
- Pages.5-8
- /
- 1988
- /
- 2093-5552(pISSN)
- /
- 2093-6214(eISSN)
Effects of Gums on Physical Properties of Oral Adhesive Tablets
Gum 종류에 따른 구강점막 부착정제의 물성 비교
- Chung, Bee-Hwan (Dong-A Pharm. Co., Ltd., Research Laboratories) ;
- Cha, Bong-Jin (Dong-A Pharm. Co., Ltd., Research Laboratories) ;
- Kwon, Jong-Won (Dong-A Pharm. Co., Ltd., Research Laboratories) ;
- Yang, Joong-Ik (Dong-A Pharm. Co., Ltd., Research Laboratories) ;
- Min, Shin-Hong (Dong-A Pharm. Co., Ltd., Research Laboratories)
- Published : 1988.03.20
Abstract
Physical properties of oral adhesive tablets prepared with four kinds of gums for topical or systemic drug delivery were investigated. Oral adhesive tablets containing 5mg of brilliant blue(BB) were prepared from direct compression. Viscosity of 2% gum solutions, water absorption, fracture resistance, stickiness of tablets, and dissolution of BB in pH 6.8 dissolution medium were tested. Acacia showed good stickiness and fracture resistance, and tragacanth showed good retarding effect on the release of BB from tablets. Therefore, tablets with varing ratios of acacia and tragacanth were prepared and their physical properties were examined. In conclusion, it was possible to obtain some adequate properties by compounding acacia and tragacanth.
Keywords