The Korean Journal of Pharmacology (대한약리학회지)
- Volume 24 Issue 2
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- Pages.203-216
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- 1988
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- 0377-9459(pISSN)
Modification of Endothelium on Contractile Response of Brain Vessels to Contracting Agents
혈관 수축제의 뇌혈관 수축반응에 대한 혈관근 내피세포의 역할
- Kook, Young-Johng (Department of Pharmacology, Chonnam University Medical School) ;
- Baik, Yung-Hong (Department of Pharmacology, Chonnam University Medical School) ;
-
Kim, Jong-Keun
(Department of Pharmacology, Chonnam University Medical School) ;
- Choi, Bong-Kyu (Department of Pharmacology, School of Medicine, Won Kwang University) ;
- Choi, Soo-Hyung (Department of Pharmacology, College of Pharmacy, Chonnam National University) ;
- Kim, Yung-In (Department of Pharmacology, College of Pharmacy, Chonnam National University)
- 국영종 (전남대학교 의과대학 약리학교실) ;
- 백영홍 (전남대학교 의과대학 약리학교실) ;
-
김종근
(전남대학교 의과대학 약리학교실) ;
- 최봉규 (전남대학교 의과대학 약리학교실) ;
- 최수형 (전남대학교 의과대학 약리학교실) ;
- 김연인 (전남대학교 의과대학 약리학교실)
- Published : 1988.12.30
Abstract
To delineate the mechanisms of vasoconstriction and vasodilation in cerebral arteries the effects of some vasoconstrictors and calcium antagonists on the basilar artery (BA) and arterial circle of Willis (WC) were examined and also the role of endothelium in the action of these drugs was investigated in pigs, cats and rabbits. In pig cerebral arteries, dose-dependent contractile responses were elicited by KCI, histamine, 5-hydroxytryptamine (5-HT) and angiotensin, but norepinephrine (NE), phenylephrine (PE) and epinephrine (EP) elicited dose-dependent contractions only under pretreatment with propranolol 10-6 M. The magnitudes of maximal contractile effects of these drugs were different from each other, and 5-H~ was the largest and angiotensin the smallest. Some calcium antagonists dose-dependently inhibited KCI (35 mM)-induced contraction and the order of potency in inhibiting the contraction was nifedipine > > diltiazem > flunarizine > oxybutynin > isosorbide dinitrate (ISDN) > glyceryl trinitrate. 5-HT (10-6 M)-induced contraction was dosedependently inhibited by nifedipine but slightly inhibited by diltiazem and ISDN. In rings with intact endothelium, KCI (35 mM)-induced contraction was not affected by acetylcholine (ACh) but
돼지, 가표 및 가토의 뇌동맥에서 기저동맥 (basilar artery, BA)과 circle of willis동맥 (WC)의 동맥환을 만들어 혈관수축제와 calcium 길항제의 효과 그리고 내피세포의 역할은 검토하였다. 돼지 BA와 WC에 서 norepinephrine (NE), phenylephrine (PE)및 epinephrine (EP)은 propranolol