Archives of Pharmacal Research

  • 제11권1호
  • /
  • Pages.7-13
  • /
  • 1988
  • /
  • 0253-6269(pISSN)
  • /
  • 1976-3786(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Cytochrome C methylation: Current Knowledge of its Biological Significance

  • Park, Kwang-Sook (Fels Research Institute, Temple University School of Medicine) ;
  • Frost, Blaise F. (Fels Research Institute, Temple University School of Medicine) ;
  • Lee, Hyang-Woo (School of Pharmacy, Sung Kyun Kwan University) ;
  • Kim, Sang-Duk (Fels Research Institute, Temple University School of Medicine) ;
  • Paik, Woon-Ki (Fels Research Institute, Temple University School of Medicine)
  • 발행 : 1988.03.01
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초록

The yeast cytochrome c gene has been recloned, and the resulting cytochrome c mRNA has been translated in rabbit reticulocyte lysate translation system. The newly synthesized apocytochrome c could be methylated by exogenously added cytochrome c-lysine N-methyltransferase. Enzymatic methylation of in vitro synthesized apocytochrome c was found to facilitate specifically its import into mitochondria of yeast, but not of rat liver.

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