YAKHAK HOEJI (약학회지)
- Volume 32 Issue 3
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- Pages.182-186
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- 1988
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Drug-Biomacromolecule Interaction(XI) -Binding of cefaclor, cefpiramide, ceftazidime and ceforanide to bovine serum albumin-
약물과 생체 고분자간의 상호작용(XI) -Cefaclor, cefpiramide, ceftazidime and ceforanide와 소혈청 단백과의 결합에 관한 연구-
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Kim, Chong-Kook
(College of Pharmacy, Seoul National University) ;
- Kwon, Kyeng-Hee (College of Pharmacy, Seoul National University)
- Published : 1988.06.29
Abstract
Binding of four cephalosporins(cefaclor, cefpiramide, ceftazidime, ceforanide) to bovine serum albumin was studied. Difference spectrophotometry was employed to evaluate the nature and the degree of association of cephalosporin-albumin complex. 2-(4'-hydroxybenzen azo) benzoic acid was used as the uv spectrophotometric probe for measuring the binding of cephalosporins to bovine serum albumin. Competitive bindings between cephalosporins and probe were observed. For the binding of cephalosporins to bovine serum albumin, three binding sites were identified. The binding constants of cefaclor, ceforanide, ceftazidime and cefpiramide were
Keywords
- Cefaclor;
- ceftazidime;
- ceforanide;
- cefpiramide;
- bovine serum albumin;
- protein-binding;
- 2-(4‘-hydroxybenzene azo) benzoic acid;
- difference spectra;
- drug interaction