Synthesis and Cardiovascular Activities of 1,4-Dihydropyridine Derivatives

1,4-Dihydropyridine 유도체들의 합성 및 혈압강하 효과

  • Published : 1988.06.29

Abstract

4-Aryl-1, 4-dihydropyridines(DHP) derived from Hantsch type condensation of aromatic aldehydes with aminocrotonates and acetoacetic esters are studied as calcium channel blocking drugs. New DHP derivatives containing alkenyl ester show fairly good cardiovascular activity in mice. Preparation of the DHP derivatives and their major biological activity are presented along with their physical data.

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