약학회지 (YAKHAK HOEJI)

  • 제32권1호
  • /
  • Pages.20-25
  • /
  • 1988
  • /
  • 0377-9556(pISSN)
  • /
  • 2383-9457(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

국소적용 소염제인 Prednisolone 유도체의 개발 및 구조와 활성의 상관관계(II)

Development and Structural Activity Relationship of New Local Anti-inflammatory Steroid, Prednisolone Deribatives

  • 발행 : 1988.02.29
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초록

New prednisolone derivatives including methyl $20{\xi}-acetoxy-prednisolonate$ have been synthesized and evaluated for local anti-inflammatory agents with reduced systemic side effect. Methyl $20{\beta}-dihydroprednisolonate$ and methyl $20{\xi}-acetoxyprednisolonate$ showed comparable anti-inflammtory activity in vivo with significantly reduced systemic side effects.

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