약학회지 (YAKHAK HOEJI)
- 제32권1호
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- Pages.6-13
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- 1988
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
기체 Chromatograph를 이용한 체액내 Volatile Free Acid의 분석연구
Volatile Free Acid Profiling of Body Fluids by Gas Chromatography
- Kim, Kyoung-Rae (College of Pharmacy, Sungkyunkwan University) ;
- Hahn, Mi-Kyoung (College of Pharmacy, Sungkyunkwan University)
- 발행 : 1988.02.29
초록
A gas chromatographic method is described for the determination of volatile free acids(VFAs) in body fluids. VFAs were trace enriched from body fluids by liquid-solid extraction using Chromosorb P as the solid sorbent and ether as the eluant. The enriched VFAs were injected in splitless injection mode onto a HP-20M fused silica capillary column. The flame ionization detector was used as the detector. The present method was applied to the profiling of VFAs in body fluids from patients suffering from the infectious disease, hepatitis. The VFAs concentrations were high in saliva of hepatitis patients and isobutyric acid detected in sera of hepatitis patients compared to healthy subjects.
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