The Korean Journal of Physiology
- Volume 22 Issue 2
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- Pages.219-230
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- 1988
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- 0300-4015(pISSN)
Effect of Glycine on the Action Potential of the Atrial Muscle and Sinus Node Cells of the Rabbit Heart
Glycine에 의한 가토심방근 및 동방결절세포의 활동전압의 변동
- Choe, Kyung-Hoon (Department of Internal Medicine, Yonsei University Wonju College of Medicine) ;
- Kim, Jin-Hyuk (Department of Physiology, College of Medicine, Hanyang University) ;
- Koh, Sang-Don (Department of Physiology, College of Medicine, Hanyang University) ;
- Shin, Hong-Kee (Department of Physiology, College of Medicine, Hanyang University) ;
- Kim, Kee-Soon (Department of Physiology, College of Medicine, Hanyang University)
- 최경훈 (연세대학교 원주의과대학 내과학교실) ;
- 김진혁 (한양대학교 의과대학 생리학교실) ;
- 고상돈 (한양대학교 의과대학 생리학교실) ;
- 신흥기 (한양대학교 의과대학 생리학교실) ;
- 김기순 (한양대학교 의과대학 생리학교실)
- Published : 1988.12.30
Abstract
The effect of glycine, structurally the most simple amino acid was investigated on the electrophysiological characteristics of the isolated superfused atrial muscle and sinus node cells of the rabbit heart. Superfusion of the sinus node cell with glycine solution (3, 5 and 8 mM) produced concentration-dependent increments of OS (overshoot potential) and MDP (maximum diastolic potential). Generally action potential amplitude increased as a result of greater increment of OS than that of MDP. The changes in action potential of the sinus node cell peaked in