실험동물에 유발시킨 피부사상균증에 대한 연구

Study of the Experimental Dermatophyte Infection in Animals

피부사상균증의 접종방법을 표준화하기 위하여 N. gypsea "+"와 A. benhamiae "+"를 가토, 기니픽, rat, mouse에 정량적으로 접종하여 다음의 결과를 얻었다. 1. 포자의 농도가 높을수록 감염률이 높았고 입상양상이 심하고 일찍 나타나서 오래 지속되었다. 2. 난전, 소피, 강제발모, 단순빈도의 순으로 감염이 잘되어 피부손상의 정도에 비례함을 알 수 있었다. 3. 피부사상균에 대한 감수성은 기니픽, 가토, rat의 순으로 높았고 mouse는 전혀 감염되지 않았다. 4. N. gypsea "+"에 비해 A. benhamiae "+"는 감염률이 높고 입상양상이 더 심하고 빨리 진행되어 조기에 조절되었다.

Experimental dermatophyte infections are essential for studying dermatophytosis. Induction of standard infections depends on control of three factors-spore dose, scarification, and species of the experimental animals. The authors evaluated the three factors in the experimental infection models, which were inoculated with quantitated spore solution on N. gypsea "+" and A. benhomiae "+" in rabit, guinea pig, rat, and mouse. The results were follows. 1. Infection was correlated with concentration of inoculum. 2. In traumatization method, abrasion with knife was the most effective for inoculation, followed by pricking, epilation, and shaving of hair in decreasing order. 3. Rabbit and guinea pig were more susceptable to dermatophyte infection rather than the rat and mouse. However, the mouse was not infected at all. 4. Guinea pig was the proper animal model for experimental dermatophytosis in susceptabillity, degree of clinical response, and duration of the infection. 5. A. benhamiae "+" showed more severe inflammation and shorter course than N. gypsea "+".