The Positive Rate for Serum Anti-HBs in Korean since the Universal Carrying Out of HB Vaccination

B형 간염백신 접종시행 이후 혈청 Anti-HBs 양성율에 관한 조사

The positive rate for serum anti-HBs was analized among 424 of HB vaccinated and 2035 of non-vaccinated cases at the Yeungnam University Hospital, Computed Automated Med-screening Center. Most of them from Kyungbook province and they had the last HB vaccination in the periods of 3 to 42months prior to this study. The followings were obtained. 1. The positive rates for serum HBsAg were 0.7% in the vaccinees, 9.6% in the non-vaccinated and 8.0% in the whole cases. 2. The positive rates for serum anti-HBs were 66.3% in the vaccinees, 47.9% in the non-vaccinated and 51.0% in the whole cases. 3. The positive rates for serum anti-HBs were 51.4% in the cases with one time of vaccination and 68.6% in the cases with two times of vaccination. on the vasis of these findings the positive rate for serum anti-HBs among the vaccinees was significantly higher than thau of non-vaccinated(P<0.05). The positive rate for seaum anti-HBs shortly after vaccination was higher than that of present our study which was made relatively long period after vaccination. As the reason a natural decrease of the titers of the serum anti-HBs can be postulated as one of the contributing factors for the discrepancy. In order to keep the serum antibody of perfect protectivity against HBV, it may be better to check the serum anti-HBs just after vaccination, follow up and take booster injection when it is needed.

저자들은 국내에서 B형 간염백신이 사용된 이래 일반주민의 혈청 anti-HBs양성율과 접종이후 장시간이 경과된 후의 접종자들의 혈청 anti-HBs 양성율을 조사하기 위하여 1986년 1월 부터 1987년 3월까지 영남의료원 건강진단센터를 방문한 2,459명을 대상으로 한 문진과 검사결과를 토대로 하여 다음의 결과를 얻었다. 1. B형 간염백신 접종군과 비접종군에서의 혈청 HBsAg 양성율은 각각 0.7%와 9.6%였으며 전체검사자중에서는 8.0%로 나타났다. 2. B형 간염백신 접종군과 비접종군에서의 혈청 anti-HBs 양성율은 각각 66.3%와 47.9%였으며 전체검사자중 51.0%였다. 3. 1회나 2회의 기본접종만 받은 군에서의 혈청 anti-HBs 양성율은 각각 51.4%와 68.6%였고 3회의 기본접종을 받은 군에서는 67.6%의 양성율을 나타냈다. 따라서 현재 일반주민의 혈청 anti-HBs 양성율은 과거보다 높아져 있으나 특히 백신접종으로 항체를 획득한 후는 시간이 경과됨에 따라 역가가 저하되는 것으로 생각되며 접종후는 혈청 anti-HBs의 출현을 확인한 후에 필요시는 더욱 정밀한 방법으로의 검사와 각자의 상황에 따른 적절한 시기의 추가 접종이 요구될 것으로 생각된다.