The Journal of the Korean Society for Microbiology (대한미생물학회지)

The Korea Society for Microbiology (대한미생물학회)
권호 표지

Effect of Inosiplex on the Cell-mediated Immune Response of Patients with Lepromatous Leprosy

Inosiplex가 나종형 나환자의 세포성 면역반응에 미치는 영향

  • Lee, Hern-Ku (Department of Microbiology and Immunology, Chonbuk National University Medical School) ;
  • Im, Suhn-Young (Department of Microbiology and Immunology, Chonbuk National University Medical School) ;
  • Park, Young-Min (Department of Microbiology and Immunology, Chonbuk National University Medical School) ;
  • Chung, Kyi-Whan (St. Mary's Clinic) ;
  • Ha, Tai-You (Department of Microbiology and Immunology, Chonbuk National University Medical School)
  • 이헌구 (전북대학교 의과대학 미생물학교실) ;
  • 임선영 (전북대학교 의과대학 미생물학교실) ;
  • 박영민 (전북대학교 의과대학 미생물학교실) ;
  • 정귀환 (전북 이리 성모의원) ;
  • 하대유 (전북대학교 의과대학 미생물학교실)
  • Published : 1987.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

This study was attempted to investigate the effect of inosiplex on the cell-mediated immunity in the patients with lepromatous leprosy. Fourteen patients received inosiplex (6gm/day) for 1 month. About 20% of the patients (3 of 14) showed conversion of the lepromin reaction and bacteriological index was significantly decreased in 3 of 7 patients. However, inosiplex administration had no effect on the lymphocyte blastogenesis to M. leprae. The clinical evolution showed a favorable activity of the drug on cutaneous lesions in some patients. The tolerance of the drug was excellent. No side effects were observed. These results suggest that inosiplex may have a moderate immunopotential value in lepromatous leprosy.

Keywords