뇨분리 대장균의 병원성과 관계된 특성

Characterization of Uropathogenic E. coli

  • 이용수 (경북대학교 의과대학 미생물학교실) ;
  • 이상화 (경북대학교 의과대학 미생물학교실) ;
  • 김정완 (경북대학교 의과대학 미생물학교실) ;
  • 설성용 (경북대학교 의과대학 미생물학교실) ;
  • 조동택 (경북대학교 의과대학 미생물학교실)
  • Lee, Yong-Soo (Department of Microbiology, School of Medicine, Kyungpook National University) ;
  • Lee, Sang-Hwa (Department of Microbiology, School of Medicine, Kyungpook National University) ;
  • Kim, Jung-Wan (Department of Microbiology, School of Medicine, Kyungpook National University) ;
  • Seol, Sung-Yong (Department of Microbiology, School of Medicine, Kyungpook National University) ;
  • Cho, Dong-Taek (Department of Microbiology, School of Medicine, Kyungpook National University)
  • 발행 : 1987.09.30

초록

A total 64 strains of Escherichia coli including 38 strains of urinary tract infection and 26 strains from other clincal sources were studied for several properties related to the virulence markers of organisms. Urinary isolates(76.3%) showed higher frequency of mannose resistant hemagglutination(MRHA) wi th human erythrocytes(A type, $Rh^+$) than the strains of control group isolated from other sources(34.6%). Seventeen strains(44.4%) of urinary isolates and 2 strains(7.7%) of control group showed hemolysis on blood agar plate. There was no significant difference in MIC's of 23 drugs between both groups of urinary isolates and control group. But they showed high frequency of resistance to ampicillin, carbenicillin, piperacillin, kanamycin, and trimethoprim, but were very susceptible to cefotaxime, moxalactam, ceftizidime, imipenem, and norfloxacine. Fourteen strains(36.8%) of urinary isolates and 10 strains(38.5%) of control group showed conjugally transferable resistance conferred to R plasmids. The urinary isolates carried one or more to 6(mean 3.4) plasmids of approximate molecular weight ranged 3.1 to 94 megadalton(Mdal) and strains of control group carried 2 to 5(mean 3.8) plasm ids of size ranged 3.6 to 130 Mdal. The size of conjugally transferable R plasmid identified with transconjugants ranged 32 to 130 Mdal.

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