Bulletin of the Korean Chemical Society

  • 제8권5호
  • /
  • Pages.421-423
  • /
  • 1987
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  • 0253-2964(pISSN)
  • /
  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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Enantioselective Reduction of Racemic Three-Membered Heterocyclic Compounds. 3. Reaction of Epoxides with B-Isopinocampheyl-9-borabicycolo[3.3.1]nonane-Potassium Hydride and Potassium B-Isopinocampheyl-9 boratabicyclo[3.3.1]nonane Systems$^1$

  • 발행 : 1987.10.20
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초록

The chiral B-isopinocampheyl-9-borabicyclo[3.3.1]nonane-potassium hydride (IPC-9-BBN-KH) and potassium B-isopinocampheyl-9-boratabicyclo[3.3.1]nonane (K IPC-9-BBNH) systems were applied to the enantioselective reduction of representative racemic epoxides, namely 1,2-epoxybutane, 1,2-epoxyoctane, 3,3-dimethyl-1,2-epoxybutane and styrene oxide. In the case of IPC-9-BBN-KH system, the optical yields are in the range of 8.3-37.4$\%$ ee. However, the system of K IPC-9-BBNH provides significantly lower optical yields, showing 7-22.5$\%$ ee. These results strongly suggest that the enantioselective coordination of chiral organoborane to the epoxy oxygen of racemic epoxides plays an important role in this resolution.

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참고문헌

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