YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

The Effect of Korean Ginseng on the Immunotoxicity of Mitomycin C

Mitomycin C의 면역독성에 미치는 고려인삼의 영향

  • Published : 1987.12.01
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Abstract

The immunopotenciating effects of ethanol extract, butanol fraction and petroleum ether extract of Korean Ginseng on the immunotoxicity of mitomycin C were investigated in mice. A single administration of mitomycin C induced an apparent but relatively transient reduction of spleen weight, hemagglutination titer, Arthus reaction, RFC and natural killer cell activity. Ethanol extract of Ginseng significantly restored spleen weight, HA titer, RFC and natural killer cell activity. Butanol fraction of Ginseng significantly restored HA titer, RFC and natural killer cell activity. Petroleum ether extract of Ginseng very significantly restored spleen weight, Arthus reaction, DTH, RFC and natural killer cell activity.

Keywords

References

  1. Am. J. Pathol v.77 Immunomodulation of tumor growth Prehn,R.T.
  2. J. Immunol. v.120 Suppressor cell activity in tumor-bearing mice Elgert,K.D.;Farrar,W.L.
  3. J.N.C.I. v.66 Inhibition of the activity of mouse natural killer cell by urethan Gorellk,E.;Herberman,R.B.
  4. J.N.C.I. v.61 Decline of natural killer cell activity in sublethally irradiated mice Hochman,P.S.;Cudkowicz,G.;Dousset,S.
  5. J. Antibiotics v.8 Immunoactive peptides, FK-156 and FK-565 Yokota,Y.;Mine,Y.;Wakai,Y.;Watanabe,Y.;Nishida,M.
  6. J.N.C.I. v.62 Natural killer cells as antitumor effector cell Herberman,R.B.;Holden,G.T.
  7. Proc. 2nd inter. ginseng symp. A cytotoxic activity of extract of Panax ginseng root against some cancer cell in-vivo and in-vitro Hwang,W.I.
  8. Proc. 3rd inter. ginseng symp. An experimental study on tumor inhibitory effect of red ginseng on mice and rat exposed to various chemical carcinogens Yun,T.K.;Yun.Y.S.;Han,I.W.
  9. Seoul J. Med. v.21 The effect of Panax ginseng on the post operative radiation complication in cervical cancer patients Chang,Y.S.;Park,C.I.
  10. J. Antibiotics v.8 The action of 7-N-(p-hydroxyphenyl) mitomycin c in suppressing murine immune response Okabe,M.;Imai,R.I.;Morimoto,M.
  11. Planta. Medica v.25 Hemolytic and its protective activity of ginseng saponin Namba,T.;Yoshizaki,M.;Tominari,T.;Hase,J.
  12. Immunol. v.38 Effect of stimulation and blokade of mononuclear phagocyte system on the delayed foot pad reaction to SRBC in mice Yoshikai,Y.;Miake,S.;Matsumoto,T.;Nomoto,K.;Takeya,K.
  13. J. Kor. Soc. Micr. v.16 Effect of inosiplex on cellular and humoral immunity Ha,T.Y.;Rhee,H.K.
  14. Brit. J. Exp. Path. v.35 Detection of complete and incomplete antibodies to egg albumin by means of a sheep red cell egg albumin antigen unit Coombs,R.R.A.;Fiset,M.L.
  15. J. Immunol. v.72 Micro methods for the study of proteins and antibiotics Stavistsky,A.B.
  16. Cell Immunol. v.3 Antigen recognition by T-lymphocytes Bach,J.F.;Darderne,M.
  17. J. Immunol. v.123 Mechanism of cell mediated cytotoxicity at the single cell level Grimm,E.;Bonavida,B.
  18. Korean J. Vet. Res. v.26 Immunobiological studies on mice treated with chemical carcinogen, 3-methylcholanthrene: Rosette formation and natural killing activity of splenic lymphocytes Song,H.J.;Kim,S.H.;Kim,J.M.
  19. Proc. 3rd Inter. Ginseng Symp. Effect of ginseng on the immune responses to influenza virus infection in mice Yeung,H.W.
  20. Agents and Actions v.15 Immunomodulatory effects of Panax ginseng C.A. Meyer in the mouse Jie,Y.H.;Cammisul,S.;Baggiocini,M.
  21. Korean J. Ginseng Sci. v.8 A study on the activities of lipid soluble ginseng extract and ginseng saponin derivatives against some cancer cells Hwang,W.I.;Oh,S.K.
  22. Chung Nam Medical J. v.9 Effects of ginseng on the side effects of anticancer agent Kim,K.J.;Kim,H.S.