약학회지 (YAKHAK HOEJI)
- 제31권3호
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- Pages.189-196
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- 1987
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Polysorbate 80이 Sulfanilamide및 Sulfacetamide 과립의 용출에 미치는 영향
Effect of Polysorbate 80 on the Dissolution of Sulfanilamide and Sulfacetamide Granules
초록
This study was carried out to investigate the effect of surfactant on the dissolution of relatively hydrophilic drugs, such as sulfanilamide (SF) and sulfacetamide (SFA) granules prepared by wet granulation. The additive incorporated in the granules is starch or microcrystalline cellulose(MCC) as an excipient, PVP as a binder, and polysorbate 80 (P-80) as a surfactant. The dissolution characteristics of SF and SFA granules in distilled water were as follows: The values of T
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