Journal of Pharmaceutical Investigation
- Volume 17 Issue 3
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- Pages.135-139
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- 1987
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Studies on Bioavailability of Commercially Available Sulfamethoxazole and Trimethoprim Tablets in Rabbits
시판 설파메톡사졸-트리메토프림정의 생체내 이용율에 관한 연구
- Choi, Jun-Shik (College of Pharmacy, Chosun University) ;
- Kim, Kyoung-Ok (College of Pharmacy, Chosun University) ;
- Burm, Jin-Pil (Junior College of Nursing, Chosun University)
- Published : 1987.09.20
Abstract
This study was attempted to investigate the dissolution rate and the bioavailability of commercially available sulfamethoxazole and trimethoprim (SMX-TM) tablets in rabbits. The dissolution test was conducted in artificial gastric juice by basket method with eight SMX-TM tablets which were chemically equivalent. According to the dissolution rate, SMX-TM tablets were divided into four groups, such as rapid, intermediate, slow and very slow groups for the bioavailability test in rabbits. The results were as follows: 1) The dissolution rate of brand A was most rapid but brand H was most slow in artificial gastric juice. 2) Area under the blood concentration curve was larger in the order of brand A > C > E > H in rabbits. 3) There was a little difference in pharmacokinetic parameters such as biological half life, absorption rate constant and
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