Pharmaceutical Studies on Ferroglycine Fumarate (I) -Studies on Glycine Complex of Ferrous Fumarate-

푸마르산철.글리신 복합체의 약제학적 연구 (제 1보) -푸마르산철의 글리신 복합체에 관한 연구-

In order to reduce gastric irritation of iron preparations, one prodrug, glycine complex of ferrous fumarate, was synthesized, identified, examined for physico-chemical properties and compared with ferrous fumarate, ferrous sulfate and ferroglycine sulfate. That novel ferroglycine fumarate (FGF) resulted in higher dissolution rate in water, artificial gastric and intestinal juice. The absorption rate constants $(K_a)$ in rat of FGF was greater and ulcerogenic dose on stomach was increased remarkably than those of iron parent materials and ferroglycine sulfate.