Griseofulvin-Phenobarbital Interaction(II) -Effects of Phenobarbital Pretreatment on Enterohepatic Recirculation of Griseofulvin in Rats-

그리세오풀린-페노바르비탈 상호작용(II) -Rat에 있어서 페노바르비탈 전처리가 그리세오풀빈의 장.간순환에 미치는 영향-

Effects of phenobarbital pretreatment on the pharmacokinetics of enterohepatic recirculating griseofulvin were investigated by comparing normal to bile duct cannulated rats and also the effects of enhanced endogeneous bile flow on the absorption of griseofulvin were studied by means of in situ recirculation method in phenobarbital-pretreated rats. Phenobarbital was administered orally for five days at the dose of 75 mg/kg/day. The influence of phenobarbital pretreatment on the absorption rate constant, area under the plasma concentration-time curve, maximum plasma concentration of orally administered griseofulvin was not found in bile duct cannulated rats. Decreased absorption clearance and apparent partition coefficient of griseofulvin in accordance with the amount of endogeneous bile juice seemed to be due to the decrease of thermodynamic activity of griseofulvin as bile forms the micelle with griseofulvin.