Effects of Prunus mume extract on experimentally Alloxan Induced Diabetes in Rabbits

매실추출물(梅實抽出物)이 가토(家兎)의 Alloxan 당뇨병(糖尿病)에 미치는 영향(影響)

These studies were conducted to investigate effects of Prunus mume extract on experimentally alloxan-induced diabetes in rabbites, antibacterial activity and acute toxicity in mice ; 1. $LD_{50}$ of Prunus mume extract(P.M.E.) was 15.25g/kg intraperitoneally in mice. 2. P.M.E. showed more significant recuperative effect compared to the control group in alloxan-induced diabetes of rabbits. 1) P.M.E. 800mg/kg bodyweight exhibited more excellent hypoglycemic effect afte 6 days and adjacent to the normal level at 14th day. 2) SGPT activity was significantly decreased after 6 days, and the blood levels of total cholesterol and urea-nitrogen were significant in 800mg/kg at 6 days and 10 days respectively. 3. In antibacterial activity test P.M.E. was active at 0.195mg/kg in Staphyllococcus aureus, 3.125mg/ml in E. coli, Enterobacter cloacae, Klebsiella oxytoca, and in Pseudomonas aeruginosa at 0.391mg/ml. 4. In histological findings, the sample groups were deeply stained, fully granulated and partial degranulation of ${\beta}-cells$, and a few vacuolar and vesicular changes of cytoplasm than alloxan treated group in proportion to the sample amounts.