생약복합제제(生藥複合製劑)의 약효연구(藥效硏究)(제34보)(第34報) -청심정천탕(淸心定喘湯)이 항히스타민작용 및 호흡기계에 미치는 영향-

Studies on the Efficacy of Combined Prepartion of Crude Drugs(XXXIV) -Effects of Chungsimjeongchun-Tang on the Anti-histamine Action and Respiratory System-

In order to investigate experimentally the clinical effects of Chungsimjeongchun-Tang that have been widely used for cardiac asthma, dyspnea and coughs secondary to the appoplexy and cardiac diseases, the water extract of Chungsimjeongchun-Tang was conducted to the effects on the anti-histamine action and respiratory system in mice, guinea-pigs, rabbits and cats. The following results of Chungsimieongchun-Tang were obtained. Spontaneous motility of the isolated ileum of mice and rabbits was strongly suppressed and contractions of the isolated ileum of mice and guinea-pigs induced by acetylcholine chloride, barium chloride and histamine were remarkably inhibited. Anti-histamine action was noted. Antitussive action on the mechanically irritative cough in cats was recognized. Expectorant action on the leakage of dye in the respiratory tract of rabbits was also shown.