Effects of Ginseng Saponin on the Antimicrobial Activities of Some Antibiotics

수종(數種) 항생물질(抗生物質)의 항균작용(抗菌作用)에 대(對)한 인삼(人蔘)사포닌 분획(分劃)의 효과(效果)

The in vitro interactions between antibiotics(ampicillin, kanamycin, cephalexin, oxytetracycline and chloramphenicol) and ginseng saponin were studied by the chessboard method against bacteria(Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Mycobacterium smegmatis). Ampicillin, kanamycin, oxytetracycline and chloramphenicol against Bacillus subtilis, and ampicillin and cephalexin against Staphylococcus aureus were synergistic in the presence of gi­nseng saponin. Whereas kanamycin, oxytetracycline and chloramphenicol against Staphylococcus aureus, and ampicillin, Kanamycin, cephalexin, oxytetracycline and chlorampheniol against Escherichia coli, and ampicillin, kanamycin, and chloramphenicol against Pseudomonas aer­uginosa, and ampicillin and chloramphenicol against Mycobacterium smegmatis were indiffer­ent in the presence of ginseng saponin. Antagonisms between antibiotics and ginseng saponin were not observed in this study.

수종 항생물질의 항균력에 대한 인삼사포닌의 영향에 대하여 시험관 내에서 항균력 실험을 실시한바 다음과 같은 결과를 얻었다. Ampicillin. kanamycin, oxytetracycline 및 chloramphenicol은 Bacills subtilis에 대하여 chloramphenicol은 Staphylococcus aureus에 대하여 상승효과를 나타냈으며 kanamycin, oxytetracy-cline 및 chloramphenicol은 Staphylococcus aureus에 대하여, ampicillin, kanamycin, cephalexin 및 oxytetracycline은 Escherichia coli에 대하여, amplicillin, kanamycin 및 chloramphenicol은 Pseudomonas aeruginosa에 대하여, ampicillin 및 chloramphenicol은 Mycobacterium smegmatis에 대하여 각각 상가효과를 나타내었으나 길항작용은 관찰되지 않았다.