대한약리학회지 (The Korean Journal of Pharmacology)
- 제23권1호
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- Pages.33-44
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- 1987
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- 0377-9459(pISSN)
칼슘 길항제가 활성화된 호중구에서의 $O_{\overline{2}}$ 의 생성, NADPH oxidase활성도 및 탐식작용에 미치는 영향
Effects of Calcium Antagonists on Superoxide Generation, NADPH Oxidase Activity and Phagocytic Activity in Activated Neutrophils
- 이정수 (중앙대학교 의과대학 약리학교실 및 한국의학연구소) ;
- 한은숙 (중앙대학교 의과대학 약리학교실 및 한국의학연구소) ;
- 이광수 (중앙대학교 의과대학 약리학교실 및 한국의학연구소)
- Lee, Chung-Soo (Department of Pharmacology, College of Medicine and Korea Medical Research Institute, Chung Ang University) ;
- Han, Eun-Sook (Department of Pharmacology, College of Medicine and Korea Medical Research Institute, Chung Ang University) ;
- Lee, Kwang-Soo (Department of Pharmacology, College of Medicine and Korea Medical Research Institute, Chung Ang University)
- 발행 : 1987.06.30
초록
면역보체가 결합되어 있는 zymosan 또는 열로 응집된 IgG에 의하여 활성화된 호중구에서의 NADPH oxidase 의존적인
NADPH oxidase dependent superoxide generation and phagocytosis in neutrophils stimulated with opsonized zymosan or heat aggregated IgG were coincided with the process of calcium uptake. The responses in activated neutrophils were enhanced with increasing concentrations of extracellular calcium and these effects were significantly inhibited by calcium chelators, EGTA and EDTA. The superoxide generation in activated neutrophils was reduced by dantrolene and chlorpromazine. Calcium antagonists, bepredil, diltiazem, verapamil, nifedipine and nimodipine effectively inhibited the calcium uptake, superoxide generation and phagocytosis in activated neutrophils, and NADPH oxidase activity was also inhibited. The results suggest that calcium antagonists may inhibit the superoxide generation and phagocytosis in activted neurtophils by the inhibition of calcium influx and by the action on intracellular redistribution of calcium and NADPH oxidase system.