Journal of Preventive Medicine and Public Health
- 제19권2호
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- Pages.244-251
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- 1986
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- 1975-8375(pISSN)
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- 2233-4521(eISSN)
항암제 Mitomycin C가 배양임파구의 자매염색분체 교환에 미치는 영향
Effects of Mitomycin C on Sister Chromatid Exchanges in Cultured Human Lympocytes
- 황인담 (전북대학교 의과대학 예방의학교실) ;
- 기노석 (전북대학교 의과대학 예방의학교실) ;
- 이정상 (전북대학교 의과대학 예방의학교실) ;
- 김남송 (전북대학교 의과대학 예방의학교실) ;
- 문태일 (전북대학교 의과대학 예방의학교실)
- Hwang, In-Dam (Department of Preventive Medicine and Public Health, Chunbuk National University Medical College) ;
- Ki, No-Suk (Department of Preventive Medicine and Public Health, Chunbuk National University Medical College) ;
- Lee, Jeong-Sang (Department of Preventive Medicine and Public Health, Chunbuk National University Medical College) ;
- Kim, Nam-Song (Department of Preventive Medicine and Public Health, Chunbuk National University Medical College) ;
- Mun, Tae-Il (Department of Preventive Medicine and Public Health, Chunbuk National University Medical College)
- 발행 : 1986.11.01
초록
항암제 mitomycin C가 정상인 배양 임파구의 SCE에 미치는 영향을 알아보기 위해 세포분열지수, 자매염색분체빈도, 세포분열주기 변동 및 염색체군별 SCE 빈도를 조사한 결과는 다음과 같이 요약할 수 있다. 1) 세포당 SCE빈도는 항암제 mitomycin C의 최저농도인
Sister chromatid exchanges(SCEs) and cell cycle kinetics were proposed as a sensitive and quantitative assay for mutagenicity and cytotoxicity in short-term cultures of phytohema-gglutinin(PHA)-stimu1ated human 1ymphocytes. Therefore, this study was performed to investigate the relation between the cytotoxic effects and sister chromatid exchanges. The resultes are summarized as follows: 1) The frequency of SCEs per cell are
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