The Journal of the Korean Society for Microbiology (대한미생물학회지)

The Korea Society for Microbiology (대한미생물학회)
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Bactericidal Activity of Normal and Cirrhotic Patients' Sera against Vibrio vulnificus

정상인 및 간경화환자 혈청의 Vibrio vulnificus에 대한 살균효과

  • Rhee, Joon-Haeng (Department of Microbiology, Chonnam National University Medical School) ;
  • Chung, Sun-Sik (Department of Microbiology, Chonnam National University Medical School)
  • 이준행 (전남대학교 의과대학 미생물학교실) ;
  • 정선식 (전남대학교 의과대학 미생물학교실)
  • Published : 1986.03.31
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Abstract

Bactericidal activity of normal and cirrhotic patients' sera against Vibrio vulnificus was investigated and compared each other as a part of the pathogenesis study of V. vulnificus septicemia. Bactericidal activity of serum against V. vulnificus was complement-dependent and the alternative pathway played the major role. V. vulnificus strains CDC A1402 and ATCC 27562 appeared serum-sensitive, and CDC C7184, clinical isolate CNUH1 and ATCC 29307 were serum-resistant. When bactericidal activity of cirrhotic sera against serum-sensitive CDC A1402 and serum-resistant CDC C7184 was compared with that of normal sera. showed slightly poorer bactericidal activity than normal sera. Especially in the case of serum-resistant CDC C7184 strain, cirrhotic sera showed statistically significant decrease(p<0.05) in their bactericidal activity.

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