대한미생물학회지 (The Journal of the Korean Society for Microbiology)
- 제21권4호
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- Pages.503-513
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- 1986
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- 0253-3162(pISSN)
Tetracycline 국소도포가 치은연하 세균분포에 미치는 영향
Longitudinal Study of the Subgingival Microbial Change after Tetracycline Topical Application
- 최광춘 (서울대학교 치과대학 치주과) ;
- 이영희 (서울대학교 치과대학 치주과) ;
- 이진용 (서울대학교 치과대학 치주과) ;
- 정종평 (서울대학교 치과대학 치주과) ;
- 손성희 (서울대학교 치과대학 치주과)
- Choi, Kwang-Choon (Department of Periodontology, College of Dentistry, Seoul National University) ;
- Lee, Young-Hee (Department of Periodontology, College of Dentistry, Seoul National University) ;
- Lee, Jin-Yong (Department of Periodontology, College of Dentistry, Seoul National University) ;
- Chung, Chong-Pyoung (Department of Periodontology, College of Dentistry, Seoul National University) ;
- Son, Seong-Heui (Department of Periodontology, College of Dentistry, Seoul National University)
- 발행 : 1986.12.31
초록
치주질환의 처치에 있어서 tetracycline의 전신적 투여는 치은연하 세균의 제거 및 감소에 매우 효과가 있는 것으로 알려져 있다. 본 연구는 전신적 투여시의 문제점 보완과 국소적 투여시 기할 수 있는 병소부위의 보다 높은 농도의 유지를 위하여 국소도포용 tetracycline gel을 제조하여 예비실험을 시행하였으며, 본 실험에서는 치주낭 깊이
Previous studies have developed the technique of topical application of tetracycline(TC) into the periodontal pockets and examined the change of clinical parameters and subgingival microbial morphotypes. The purpose of this study was to longitudinally examine the clinical and microbiological effects of topically applied TC in a double-blind and split-mouth design. Thirteen patients with moderate periodontitis, who were treated with or without TC application and scaling treatment, were examined. TC gel(3%) was used to apply into the selected periodontal pockets twice a week for 2 weeks. During the experiment, clinical parameters and subgingival microbial morphotypes were examined, and for isolation of black-pigmented Bacteroides(BPB) and streptococci, an anaerobic sample culturing was done at week 0, 2, and 7. In clinical observation the TC-scaled group exhibited a significant decrease of Gingival Inflammatory Index, Plaque Index, Sulcus Bleeding Index, pocket depth, and gingival crevicular fluid when compared to the TC-unsealed, placebo-scaled, and placebo-unsealed groups. The result of microbial morphotype observation showed a significant increase of coccal form and a decrease of spirochetes in the TC-scaled, TC-unscaled, and placebo-scaled groups. The culture study of streptococci revealed that TC with scaling treatment resulted in a significant increase of S. sanguis I at week 2, but its proportion had returned to the base line level. The anaerobic culture study showed that BPB was significantly reduced in the TC-scaled and TC-unsealed groups at week 7. Among BPB species, B. intermedius declined significantly with time treatment(week 2 and 7) in the TC-scaled and TC-unsealed groups. These results suggest that the settled pathogenic microflora can be succeeded by nonpathogenic microflora in periodontal pockets after TC treatment.