Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Preparation of Glutamic Acid-Leucine Copolymer Containing Indomethacin for Controlled Delivery

  • Yeom, Young-Il (Department of Biological Science & Engineering, The Korea Advanced Institute of Science & Technology) ;
  • Kim, Hyun-Pyo (Department of Biological Science & Engineering, The Korea Advanced Institute of Science & Technology) ;
  • Kim, Hack-Joo (Department of Biological Science & Engineering, The Korea Advanced Institute of Science & Technology) ;
  • Byun, Si-Myung (Department of Biological Science & Engineering, The Korea Advanced Institute of Science & Technology) ;
  • Kim, Nam-Deuk (College of Pharmacy, Pusan National University)
  • Published : 1986.06.20
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Abstract

A series of copolypeptides of glutamic acid and leucine have been synthesized by N-carboxy-${\alpha}$-amino acid anhydride procedure and cast to form injectable microparticulate monolithic devices in which indomethacin was physically dispersed. With these devices, various release properties and possible clinical application were studied. The release rate of the drug had a close relationship with the monomer composition of the copolymer matrix as well as the environmental pH condition. The monolithic device of glutamic acid/leucine = 50/50 was found to be the most promising one as a ploymeric delivery system of indomethacin. The intrinsic viscosity of this copolymer was 4.35 dl/g and the release rate was 18.5${\mu}g/g/day$.

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