DOI QR코드

DOI QR Code

Oxidations of Cyclohexanols by N-Bromosuccinimide and Sodium Hypochlorite

  • Published : 1986.04.20

Abstract

The axial alcohol in trans-3,3,5-trimethylcyclohexanol was oxidized more readily than the equatorial alcohol in cis-3,3,5-trimethylcyclohexanol by NBS in aqueous dioxane. On the contrary, the equatorial alcohol was preferentially oxidized to the axial one by 10% aqueous sodium hypochlorite in the presence of tetrabutylammonium hydrogen sulfate (TBHS). The specificity indicates the presence of two different mechanism. In acidic medium, the cleavage of C-H bond is rate determining step while the reactivity of the alcohol is important in the presence of TBHS. The mechanism in basic medium without TBHS will be discussed.

Keywords

References

  1. Chem. Rev. v.63 R.Filler
  2. J. Am. Chem. Soc. v.71 L.F. Fieser;S.Rajagopalan
  3. J. Am. Chem. Soc. v.72 L.F. Fieser;S.Rajagopalan
  4. J. Am. Chem. Soc. v.89 N.C. Deno;N.H. Potter
  5. J.Chem.Soc.Perkin Trans.Ⅱ B.Shah;K.K.Banerji
  6. Indian J. Chem. v.18B G.Goplakrishnan;B.R.Pai;N.Venkatasubramanian
  7. Bull.Chem. Soc. Japan v.34 J.Kawanami
  8. Tet. Lett. G.A.Lee;H.H.Freedman
  9. J.Am. Chem. Soc. v.98 P.Muller;J.Perlberger
  10. Bull. Inst. Basic Sci., Inha Univ. v.5 K.Chung;T.Chang;C.Yoon
  11. Bull. Inst. Basic Sci., Inha Univ. v.6 K. Chung
  12. Synthesis S.Hanessian;D.H. Wong;M.Therien
  13. J.Amer. Chem. Soc. v.71 F.H.Westheimer;N.Nicolaids
  14. Progr. Phys.org. Chem. v.13 M.J.Kamlet;J.L.M. Abboud;R.W.Taff

Cited by

  1. Effect of Micellar Aggregates on the Kinetics of Dextrose Oxidation by N-Bromosuccinimide vol.47, pp.2, 1986, https://doi.org/10.3139/113.110057
  2. Kinetic Treatment of the Reaction of Fructose and N-Bromosuccinimide in Cationic/Anionic/Nonionic Micelles vol.2014, pp.None, 2014, https://doi.org/10.1155/2014/791563
  3. Use of Bromine and Bromo-Organic Compounds in Organic Synthesis vol.116, pp.12, 1986, https://doi.org/10.1021/acs.chemrev.5b00400