Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Synthesis of Nucleophilic Adducts of Thiols (Ⅶ). Addition of Thioglycolic Acid to $\alpha$-Cyano-$\beta$-phenylacrylic Acid Derivatives

  • Huh, Tae-Sung (Department of Chemistry Song Sim College for Women) ;
  • Lee, Hee-Jong (Department of Chemistry Song Sim College for Women) ;
  • Han ,In-Sup (Department of Chemistry, Kangweon National University) ;
  • Kim, Tae-Rin (Department of Chemistry, Korea University)
  • Published : 1986.02.20
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Abstract

Reaction of ${\alpha}-cyano-{\beta}-phenylacrylic$ acid derivatives (Ⅰ) with thioglycolic acid in the molar ratio of 1:2 in saturated sodium bicarbonate solution yielded 3-(4'-oxo-2'-thiazolin-2'-yl)-2-phenyl-4-oxotetrahydrothiophene derivatives (V). Thioglycolic acid was found to be added not only to carbon-carbon double bond but also to carbon-nitrogen triple bond and those adducts were cyclized to V.

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References

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