HEPATOTOXICITY OF T-2 TOXIN IN RATS

T-2 toxin was given to rats(Spargue Dawley) with a 4mg/kg and 2mg/kg dose p.o. Data was based on the T-2 toxin 4mg/kg treated group except for counting of acidophil bodies. GPT activities increased significantly from 0.5 to 10 hours. GOT activities were also increased at 1 and 5 hours significantly and the relative weights of liver were increased at 0.5 and 5 hours significantly. There were slight necrotic foci in microscopic observation. There was dose-dependent trend for the frequency of the acidophil body between the 4mg/kg treated group and the 2mg/kg treated group.