Toxicological Research
- Volume 2 Issue 2
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- Pages.89-102
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- 1986
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- 1976-8257(pISSN)
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- 2234-2753(eISSN)
HEPATOTOXICITY OF T-2 TOXIN IN RATS
- Kang, Tae-Gyu (College of Veterinary Medicine Seoul National University) ;
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Lee, Yong-Soon
(College of Veterinary Medicine Seoul National University)
- Published : 1986.12.01
Abstract
T-2 toxin was given to rats(Spargue Dawley) with a 4mg/kg and 2mg/kg dose p.o. Data was based on the T-2 toxin 4mg/kg treated group except for counting of acidophil bodies. GPT activities increased significantly from 0.5 to 10 hours. GOT activities were also increased at 1 and 5 hours significantly and the relative weights of liver were increased at 0.5 and 5 hours significantly. There were slight necrotic foci in microscopic observation. There was dose-dependent trend for the frequency of the acidophil body between the 4mg/kg treated group and the 2mg/kg treated group.
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