Toxicological Research
- Volume 2 Issue 1
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- Pages.31-36
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- 1986
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- 1976-8257(pISSN)
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- 2234-2753(eISSN)
EFFECT OF GLYCYRRHETINIC ACID ON PYRIDINE TOXICITY IN MOUSE
- Keun Huh (Department of Phamacology, College of phamacy, Yeungnam University) ;
- Lee, Sang-Il (Department of Phamacology, College of phamacy, Yeungnam University) ;
- Park, Jong-Min (Department of Phamacology, College of phamacy, Yeungnam University) ;
- Chung, Jung-Rok (Department of Phamcy Dogsan Medical Center)
- Published : 1986.06.01
Abstract
The present work was undertaken to investigate the effect of glycyrrhetinic acid on pyridine toxicity. When glycyrrhetinic acid was pretreated, pyridine-induced CNS depression and mortality were decreased. A striking enhancement of serum transaminase activities after pyridine administration was markedly decreased by glycyrrhetinic acid pretreatment. It was also observed that the hepatic microsomal aniline hydroxylase activity, which is concerned with pyridine metabolism, was significantly increased in glycyrrhetinic acid pretreated mice.