YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Synthesis and Antibiotic Activities of Poly (acrylic acid) Modified $\beta$-Lactam Cyclics

$\beta$-락탐계 항생물질의 폴리아크릴산 중합체의 합성 및 항균성

  • 진정일 (고려대학교 화학과) ;
  • 최성모 (고려대학교 화학과) ;
  • 장민선 (동아제약주식회사 중앙연구소) ;
  • 민신홍 (동아제약주식회사 중앙연구소)
  • Published : 1986.10.01
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Abstract

A series of modified poly(acrylic acid)'s containing different levels of 6-aminopenicillanic acid (6-APA), 7-aminocephalosporanic acid (7-ACA) and 6-[D-(-)-$\alpha$-aminophenyl acetamido] penicillanic acid (ampicillin) as pendant groups were prepared. Antibiotic activities of the newly prepared drugs were examined against the various gram-positive and gram-negative bacteria. It was found that ampicillin modified composition posses antibiotic activities against the gram-negative as well as the gram-positive bacteria.

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