YAKHAK HOEJI (약학회지)
- Volume 30 Issue 5
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- Pages.208-213
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- 1986
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Drug Interaction of Rifampicin and Isotiazid
리팜피신과 이소니아짓의 약물상호작용
Abstract
Rifampicin suspension was administered orally at a does of 34mg/kg to six rabbits after 5, 10 and 20mg/kg pretreatment of isoniazid twice daily for 9 days. The blood level of rifampicin was decreased significantly by isoniazid 10mg/kg 20mg/kg pretraetment. The renal clearance(CLr) of rifampicin was increased by isoniazid 20mg/kg and the biliary clearance(CLb) was incresed by isoniazid 10mg/kg and 20mg/kg pretreatmetn. Elimination rate constant(K) and time to reach maximum concentration(tmax) were increased by isoniazicl pretreatment. But half-life and maximum concentration(C max) were decreased. Relative bioavailability was decreased significantly by isoniazid 10mg/kg and 20mg/kg pretreatment.
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