Archives of Pharmacal Research
- Volume 9 Issue 3
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- Pages.189-191
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- 1986
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Effects of diterpene acids on malondialdehyde generation during thrombin induced aggregation of rat platelets
- Kosela, Soleh (Department of Chemistry, Universitas Indonesia) ;
- Rasad, Asri (Department of Chemistry, Universitas Indonesia) ;
- Achmad, Sjamsul-Arifin (Chemistry Department. Institute Technology Bandung) ;
- Wachyudi-Wicaksonon (Department of Chemistry, Universitas Indonesia) ;
- Baik, Soung-Kyung (Natural Products Research Institute, Seoul National University) ;
- Han, Yong-Nam (Natural Products Research Institute, Seoul National University) ;
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Han, Byung-Hoon
(Natural Products Research Institute, Seoul National University)
- Published : 1986.09.01
Abstract
The effects of diterpene acids (i. e. pimaradienoic acid, kaurenoic acid, hydroxy cembratrienoic acid and dihydroxycembratetraenoic acid) on malondialdehyde generation by rat platelets in response to thrombin were studied. All the compounds inhibited the generation of MDA.
Keywords
- Diterpene acids;
- platelet;
- inhibition of malondialdehyde generation;
- Aralia continentalis;
- Cleome viscosa