Archives of Pharmacal Research
- Volume 9 Issue 2
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- Pages.111-114
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- 1986
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Effect of Bile Salt on the Pharmacokinetics of Bretylium in the Rat (I) - Increased Lipophiiicity of Bretylium by Ion-Pair Complexation with Taurodeoxycholate -
- Shim, Chang-Koo (College of Pharmacy, Seoul National University) ;
- Chung, Suk-Jae (College of Pharmacy, Seoul National University) ;
- Lee, Jeong-Uk (College of Pharmacy, Seoul National University) ;
- Lee, Min-Hwa (College of Pharmacy, Seoul National University) ;
- Kim, Shin-Keun (College of Pharmacy, Seoul National University)
- Published : 1986.06.01
Abstract
Bretylium tosylate is a quaternary ammonium compound used for the treatment of ventricular fibrilation in humans. It is advantageous to other cationic compound in the study of biliary excretion in that negligible amount is bound to plasma protein and metabolite is not likely is to be formed. Some researchers reported that the formation of ion-pair complex caused to increase the lipothilicity of cationic compound. The partition of bretylium between water and organic phase was increased with the addition of sodium taurodeoxycholate. Also sensitive gas chromatographical assay procedure using flame ionization detector was studied. This procedure can detect as low as 0.1 mg/ml using 0.1 ml biological sample, but contamination by previous injection is the major problem of this method.
Keywords
- Bertylium tosylate;
- Taurodeoxycholate;
- lon-pair complex Apparent partitition coefficient;
- Lipophilicity;
- Electron capture detector;
- Flame ionization detector;
- Capillary column gas chromatography;
- Splitless method;
- Sensitive determination of bretyllin