생약의 수치(修治)에 따른 약호연구(제2보) : 지모(知母)의 진정, 수면효과 및 장관평활근에 미치는 영향

Studies on Efficacy of Crude Drug by Processing (II): Sedative Action, Prolonged Effect of Sleeping Time and Effects on Ileum-Smooth Muscle of Anemarrhenae Rhizoma

Anemarrhenae Rhizoma has been clinically used as a sedative drug in oriental medicine. We observed the sedative action and effect on the movement of isolated-ileum with each water extract of Anemarrhenae Rhizoma (F-I), saline solution treated preparation (F-II) and 25% ethanol treated preparation (F-III). The results obtained were summerized as follows; 1) Sedative actions were recognized with F-I, F-II and F-III. 2) Prolonged effect of sleeping time was recognized significantly with F-I, F-II and F-III. 3) Each fraction of Anemarrhenae Rhizoma showed the released action on the isolated-ileum of the mouse, rat, rabbit and guinea pig, and antagonic action against contraction induced by acetylcholine, barium chloride and histamine. Thus the mechanism in the released action of the smooth muscle was partly considered as the direct dependence of the smooth muscle.