Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Determination of Higenamine in the Commercial Aconiti Tuber and Its Pharmaceutical Preparations

  • Hahn, Young-Hee (Department of Chemistry, Sang Myung Women's College and Natural Products Research Institute, Seoul National University) ;
  • Cheong, Kyo-Soon (Department of Chemistry, Sang Myung Women's College and Natural Products Research Institute, Seoul National University) ;
  • Paik, Seung-Whan (Department of Chemistry, Sang Myung Women's College and Natural Products Research Institute, Seoul National University) ;
  • YunChoi, Hye-Sook (Department of Chemistry, Sang Myung Women's College and Natural Products Research Institute, Seoul National University)
  • Published : 1986.03.30
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Abstract

A cardiac principle of Aconiti tuber, higenamine was analyzed with a differential pluse voltammetry employing a glassy carbon electrode. The peak potentials for the oxidation of higenamine were varied depending on the pH of the media. Higenamine at the concentration of $5.4{\times}10^{-7}M$ (0.146ppm) was easily determined using a pH 7.0 phosphate buffer. The amounts of higenamine in the crude Aconiti tuber and tablets containing A. tuber were determined by a standard addition method after extracting with methanol, partitioning with a mixture of $H_2O$ and $CHCl_3$, and freeze-drying the aqueous layer.

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