Korean Journal of Pharmacognosy (생약학회지)
- Volume 17 Issue 1
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- Pages.91-99
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- 1986
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- 0253-3073(pISSN)
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- 2288-9299(eISSN)
Hepatic Drug Metabolism Modifier from Arils of Myristica fragrans
- Shin, Kuk-Hyun (Natural Products Research Institute, Seoul National University) ;
- Woo, Won-Sick (Natural Products Research Institute, Seoul National University)
- Published : 1986.03.30
Abstract
The single treatment of mice with steam distillate, non-volatile ether extract and methanol extract from mace (Arils of Myristica fragrans) caused a significant prolongation of hexobarbital-induced narcosis and increase in strychnine toxicity as well as a significant decrease in hepatic microsomal drug metabolizing enzyme activities. On 7 consecutive daily administrations, however, the duration of hypnosis was markedly shortened and significant increases in the hepatic enzyme activities were shown. With systematic fractionation by