Antiepileptic Therapy for Latent Epilepsy

잠복성 간질에 대한 항간제 투여의 뇌파상 효과

The clinical state with EEG pattern similar to interval discharge of epileptics is named as latent epilepsy, which does not necessarily mean that the patient will develop epilepsy later. However, since there is possibility of developing epilepsy on later date, antiepileptic mainly dilantin was tried to control the abnormal EEG. Since January to October 1985, total 580 headache sases with more than moderately abnormal EEG Visited the Neurology clinic. Among them 162 cases with interval seizure pattern (ISP) of epilepsy were selected for the study. The main ISP was 1. diffuse theta and/or delta bursts and 2. spikes. Since the study is only analysis of clinical treatment of 162 cases Without previous planning based on financial aid, about 30% of the patients did not return after the 1st EEG examination, in 42% failed to follow the EEG after the treatment and only remaining 28% of the cases were studied. Among 29 patients who were treated with Dilantin 100mg tid po, 16 improved and 13 not. Of the 13, 4 showed partial Improvement and partial progression. Case 1. In 4 weeks of antiepileptic the ray (AR), spikes disappeared but in 2 months developed bursts. Case 2. In 17days of AR, spikes and bursts disappeared but in 3 months bursts reccured. Case 3. In 1 week of AR, bursts disappeared but spikes developed. Case 4. In 3 months of AR, no change of spikes and bursts and she discontinued the AR. In 6 months she developed grandmal seizure. Eighteen cases, treated with other drugs except antiepileptics, all showed improvement. The other drugs were vincaprol, polygammalon, aronamin, ATP and hydergine. The improved cases had spikes more often than theta bursts. In view of the small number of the cases due to dropping most patients out of present study, it is considered meaningless to perform statistical analysis. Further well planned study With more patients is to be expected.

1985년 1월부터 10월까지 본 영남대학교 의과대학 부속병원 신경과 외래를 찾은 두통환자 중에서 뇌파상 중등도 이상의 이상이 있는 환자가 580명이었다. 이들 중에서 간질의 간헐기 뇌파와 유사한 소견을 보이는 162명 환자들을 대상으로 투여한 항간제 및 뇌영양제 등을 단독 혹은 병용 투여한 한 후 치료효과를 분석한 결과 항간제투여군 29예에서 호전이 16예, 무변화가 13예이고, 항간제를 쓰지 않고 뇌 영양제를 사용했던 18예에서는 전예에서 호전을 보았다. 한편 항간제를 사용한 33예와 사용하지 않은 35예에서는 뇌파추적을 하지 못하였다. 수가 적어서 통계학적인 고찰은 하지 않았으며 앞으로 계획석인 계속 연구가 요망된다.