Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Kinetics of Hydrogen-Deuterium Exchange of 8-CH Groups in Adenosine 5$^\prime$-Monophosphate and Guanosine 5$^\prime$-Monophosphate by Laser Raman Spectroscopy

  • Kim, Sang-Kyu (Department of Chemistry, College of Natural Sciences, Seoul National University) ;
  • Kim, Myung-Soo (Department of Chemistry, College of Natural Sciences, Seoul National University) ;
  • Suh, Se-Won (Department of Chemistry, College of Natural Sciences, Seoul National University)
  • Published : 1985.10.20
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Abstract

The rate constants of the hydrogen-deuterium exchange of 8-CH groups in 5'-rAMP and 5'-GMP were measured by laser Raman spectroscopy. The Arrhenius activation energies calculated from the rate constants measured as a function of temperature were similar for both compounds. However, the effects of pD on exchange rate constants were different for the two compounds. Our kinetic data support the exchange reaction mechanism involving an ylide type intermediate.

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